Cryopyrin-Associated Periodic Syndromes, or CAPS, are a group of rare, inherited conditions that share a number of symptoms in
common, including recurrent rash, fever/chills, joint pain, fatigue, and eye pain/redness. There are three related disorders classified as
auto-inflammatory diseases that make up CAPS: Familial Cold Auto-inflammatory Syndrome (FCAS), Muckle-Wells Syndrome (MWS), and Neonatal-Onset
Multisystem Inflammatory Disease (NOMID).
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FCAS
FCAS is a rare, inherited inflammatory disorder characterized by recurrent attacks of rash, fever/chills, joint pain, fatigue, and eye pain/redness,
triggered by exposure to cooling temperatures. Onset of FCAS occurs during early childhood or adolescence and persists throughout the patient's life.
MWS
MWS is a form of CAPS characterized by recurrent rash, fever/chills, joint pain, fatigue, and eye pain/redness. MWS symptoms are triggered by
random, unknown factors and possibly exercise, stress, or cold. MWS is often associated with hearing loss and/or amyloidosis, an accumulation
of amyloid protein in organs such as the kidney.
NOMID
NOMID, also known as Chronic Infantile Neurologic Cutaneous Articular (CINCA) syndrome, is a rare, congenital, systemic, inflammatory
condition distinguished by recurrent rash, fever/chills, joint pain, fatigue, eye pain/redness, and significant central nervous system
(CNS) complications. Symptoms of NOMID generally appear shortly after birth. NOMID is the most severe form of CAPS.